NOS3 Support Bundle — Seeking Health Skip to content
NOS3 Support Bundle

See what's included?

Supplement bottle labeled 'Homocysteine Nutrients' by Seeking Health on a white background
281 Reviews

Homocysteine Nutrients
Vitamin C Plus
210 Reviews

Vitamin C Plus
Supplement bottle labeled 'Glutathione with Cofactors' by Seeking Health on a white background
214 Reviews

Glutathione with Cofactors Lozenges ( formerly Glutathione Plus Lozenge )
Container of Optimal Electrolyte supplement with flavor options on a white background
1673 Reviews

Optimal Electrolyte

NOS3 Support Bundle

You have a NOS3 variant. Your nitric oxide production needs targeted support.
If circulation, blood pressure, or cardiovascular health are on your mind — this bundle was built for you.
NOS3 is the enzyme responsible for producing nitric oxide — the molecule that tells your blood vessels to relax, open up, and allow healthy blood flow. When NOS3 variants reduce its efficiency, the downstream effects can show up as poor circulation, cold extremities, elevated blood pressure, or slow recovery.

This bundle works from four angles: supporting the clearing of upstream methylation roadblocks that impair NOS3, protecting the nitric oxide it produces from oxidative destruction, shielding the vessel lining where NOS3 lives, and supporting the mineral balance your blood vessels need to respond.†
$167
$167 - $167
$167
$133.60
$133.60 - $133.60
$133.60

See what's included?

Supplement bottle labeled 'Homocysteine Nutrients' by Seeking Health on a white background
281 Reviews

Homocysteine Nutrients
Vitamin C Plus
210 Reviews

Vitamin C Plus
Supplement bottle labeled 'Glutathione with Cofactors' by Seeking Health on a white background
214 Reviews

Glutathione with Cofactors Lozenges ( formerly Glutathione Plus Lozenge )
Container of Optimal Electrolyte supplement with flavor options on a white background
1673 Reviews

Optimal Electrolyte
Third Party Tested Third Party Tested
High End Ingredients High End Ingredients
60-day Return Policy 60-day Return Policy
Free Shipping Free Shipping

Or Choose Individual Products

Homocysteine Nutrients
4.9
Rated 4.9 out of 5 stars
281 Reviews
| Review Summary

Homocysteine Nutrients

Support methylation and clear the roadblock upstream so NOS3 can function properly†
$37

What it does for NOS3

High homocysteine damages blood vessel linings and directly impairs NOS3 (the enzyme that produces nitric oxide). This formula provides methylation support (B12, folate, B6, TMG) to keep homocysteine in check — essentially “cleaning up” the environment so NOS3 can function . Think of it as clearing the roadblock upstream.†

When to take

Morning, with or without food. The B vitamins can be mildly energizing, so avoid evening doses if sleep-sensitive.

How to take

Follow label dosing. If you’re new to methylation support, consider starting at half the recommended dose for the first week to assess tolerance. This is an all-in-one, so you don’t need separate methylfolate/B12 if you’re using this.

Signs you may be taking too little

Homocysteine remains elevated on bloodwork, persistent fatigue or brain fog, cold hands/feet or poor circulation, cardiovascular markers not improving.

Signs you may be taking too much

Overmethylation symptoms —, irritability, poor sleep restlessness, headaches, muscle tension, or feeling “revved up” in an unpleasant way. Back down to a lower dose if these appear.
Vitamin C Plus
4.6
Rated 4.6 out of 5 stars
210 Reviews
| Review Summary

Vitamin C Plus

Protects nitric oxide from oxidative destruction so it can reach your blood vessels†
$40

What it does for NOS3

Nitric oxide is fragile — it gets destroyed by oxidative stress almost immediately after it’s made. Vitamin C is one of the primary antioxidants that protects nitric oxide so it can actually reach your blood vessels and do its job. The powder form allows flexible dosing so you can find your personal sweet spot.†

When to take

Split into 2–3 doses throughout the day for sustained antioxidant coverage (morning, midday, and/or afternoon). Vitamin C is water-soluble and clears the body within a few hours, so spreading it out beats one large dose. Taking with food can reduce any stomach sensitivity.

How to take

Mix into water or juice as directed on the label. Start with a lower dose and gradually increase. “Bowel tolerance” is your guide — your body will absorb what it needs and flush the rest.

Signs you may be taking too little

You’re doing everything else right but still not seeing benefits to healthy circulation, energy, or blood pressure. Oxidative stress markers are high. Skin bruises easily or heals slowly. Experience illnesses frequently or recover slowly.

Signs you may be taking too much

Loose stools or diarrhea — this is the classic signal you’ve hit your limit. Stomach cramping, gas, or nausea can also occur. Simply back off to the previous dose that felt comfortable. Your bowel tolerance may increase when you’re under stress or fighting illness, so it’s not a fixed number.
Glutathione with Cofactors Lozenges ( formerly Glutathione Plus Lozenge )
4.8
Rated 4.8 out of 5 stars
214 Reviews
| Review Summary

Glutathione with Cofactors Lozenges ( formerly Glutathione Plus Lozenge )

Master antioxidant support — protects the vessel lining where NOS3 lives and works†
$50

What it does for NOS3

Glutathione is considered the body’s “master antioxidant” — it protects the endothelium (vessel lining) where NOS3 lives and works. Damaged endothelium means poor nitric oxide production, no matter how good your other inputs are. Glutathione also recycles vitamin C, so the two work synergistically. The added cofactors (typically B vitamins, selenium, and/or milk thistle) support your body’s ability to both use and regenerate glutathione — you’re not just supplementing it, you’re helping your body make more of its own.†

When to take

Morning on an empty stomach (20–30 minutes before food) typically gives best absorption. Some people take a second dose in the afternoon if under high oxidative stress.

How to take

Let the lozenge dissolve slowly under your tongue or against your cheek rather than chewing or swallowing it whole. Let it dissolve for about 3–5 minutes then swallow. For best results, avoid eating or drinking for a few minutes afterward.

Signs you may be taking too little

Slow recovery from exercise or illness, persistent fatigue despite other support, high inflammatory or oxidative markers on labs, skin looking dull or aging faster than expected, chemical/fragrance sensitivities (suggests detox pathways are sluggish).

Signs you may be taking too much

Glutathione is generally very safe, but some people experience detox-like symptoms if their body starts mobilizing stored toxins faster than it can clear them — headaches, fatigue, or feeling “off.” This usually means you need more drainage/detox support (electrolytes, hydration, binders) rather than less glutathione, but reducing the dose temporarily can help.†
Optimal Electrolyte
4.6
Rated 4.6 out of 5 stars
1,673 Reviews
| Review Summary

Optimal Electrolyte

Supports hydration, minerals, and the vascular tone nitric oxide needs to work†
$40

What it does for NOS3

Proper mineral balance — especially magnesium and potassium — directly affects vascular tone and how well your blood vessels can relax in response to nitric oxide. Dehydration also thickens blood and stresses vessel walls. Electrolytes support the downstream environment where nitric oxide needs to work.†

When to take

Morning or throughout the day. Especially important during/after exercise, in hot weather, or if you consume caffeine (which depletes minerals).

How to take

Mix into water as directed and sip throughout the day rather than drinking all at once. Consistent hydration beats occasional mega-doses.

Signs you may be taking too little

Muscle cramps, especially at night. Fatigue despite adequate sleep. Headaches, particularly after exercise or coffee. Blood pressure not responding to other interventions. Feeling “tight” or constricted.

Signs you may be taking too much

Loose stools (magnesium is the usual culprit), nausea, or feeling flushed. If you’re urinating constantly and it’s completely clear, you may be over-hydrating and diluting electrolytes — back off volume and let thirst guide you.

What This BundleHelps Address

  • Homocysteine Nutrients — methylation support to clear the roadblock upstream†
  • Vitamin C Plus Powder — protects nitric oxide from oxidative destruction†
  • Glutathione With Cofactors — shields the vessel lining where NOS3 works†
  • Optimal Electrolyte — mineral balance for healthy vascular tone and hydration†

It’s not just about making more nitric oxide — it’s about protecting what you make, clearing what’s in the way, and giving your blood vessels the environment they need to respond.

What Our Customers Say

Susan
Optimal Electrolyte
I love that these electrolytes have more magnesium and less sodium - just what our bodies need. The green apple flavor is really good and refreshing too.
L
It works!!!
This seriously works. My homocysteine was in the 40s and it has lowered it to below 10 within a couple months. I am so grateful I found this!
Claire
Glutathione with Cofactors
I like this formula better with the cofactors than just the plain glutathione with no cofactors.
Angie
Great for the family
Great lineage for the family. Vitamin C is always a great one to have on hand.
Terri
Watermelon strawberry
This is the best flavor yet! It keeps me hydrated and energized. I’m sensitive to supplements and this works great. Highly recommend!

You’re in the right place

When the foundation is supported
everything works better
Start with daily, genetics-informed nutrients.

Stay up to date on our latest product releases, events, and more!

Receive 10% off your order when you download our App!