COMT Slow Support - Dirty Genes®
The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. Slow COMT may lead to high estrogen or too many neurotransmitters (dopamine, norepinephrine, and epinephrine). This could make you feel irritable, tense, or unable to relax. You might not sleep well and you might even have detoxification or hormone problems.
The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. Slow COMT may lead to high estrogen or too many neurotransmitters (dopamine, norepinephrine, and epinephrine). This could make you feel irritable, tense, or unable to relax. You might not sleep well and you might even have detoxification or hormone problems.
Slow COMT activity may mean that you don’t have enough SAMe or too much homocysteine. Nutrients that support a balanced COMT gene include vitamin B12, other B vitamins, folate, and magnesium. Your MTHFR gene works closely with COMT, so you also need nutrients for methylation, like betaine and SAMe.
To support your slow COMT gene, you need supplementation that promotes the optimal way your gene should function. Hydrox-Adeno B12 and Folinic Acid provide bioavailable sources of vitamin B12 and folate in methyl-free versions, which might be easier to tolerate if you have a sensitive brain.
Explore other supportive nutrients for your COMT gene below, like Optimal Magnesium , Adrenal Support, or Optimal Sleep.
All Products
Best Sellers
Featured Products
Shop by
All Products
Best Sellers
Featured Products
-
Promote healthy energy production and mood without additional B12 and folate with B Minus.†
B Minus—A potent formula containing 6 essential B vitamins that’s free from B12 and folate to allow for customization of these two essential nutrients.†
Original price $32 - Original price $192Original price $32 - Original price $192Original price $96$96$32.00 - $163.20Save 67%$32.00 - $163.20Original price $32.00 - Original price $192.00Original price $32.00 - Original price $192.00Original price $96.00$32.00 - $163.20$32.00 - $163.20Current price $32$32.00 - $163.20Current price $32 -
Foster a healthy mood, motivation, learning, and memory with Dopamine Nutrients.†
Dopamine Nutrients—Designed to support healthy dopamine levels and the health of the cells that make it with key ingredients like L-Tyrosine, Ginkgo Biloba Extract, and Royal Jelly Concentrate.†
Sale
SaleBOGOOriginal price $49 - Original price $294Original price $49 - Original price $294Original price $147SALE $147$49.00 - $249.90Save 67%$49.00 - $249.90Original price $49.00 - Original price $294.00Original price $49.00 - Original price $294.00Original price $147.00$49.00 - $249.90$49.00 - $249.90Current price $49$49.00 - $249.90Current price $49 -
Prioritize your gut health with the comprehensive, nutrient-dense blend found in Gut Nutrients!†
Gut Nutrients—A blend of herbs and nutrients that synergistically supporting healthy digestion, GI barrier, and immune system function. L-Glutamine is added for enhanced gut lining support.†
Original price $50 - Original price $300Original price $50 - Original price $300Original price $150$150$50.00 - $255.00Save 67%$50.00 - $255.00Original price $50.00 - Original price $300.00Original price $50.00 - Original price $300.00Original price $150.00$50.00 - $255.00$50.00 - $255.00Current price $50$50.00 - $255.00Current price $50 -
Start your kids’ day off right with the bioavailable nutrients they need to keep going with Kids Multivitamin Chewable MF!†
Kids Multivitamin Chewable MF—A comprehensive multivitamin and multimineral with methyl-sensitive kids in mind in a great-tasting, kid-approved, and sugar-free chewable.†
ImprovedHSA / FSAOriginal price $30 - Original price $180Original price $30 - Original price $180Original price $90$90$30.00 - $153.00Save 67%$30.00 - $153.00Original price $30.00 - Original price $180.00Original price $30.00 - Original price $180.00Original price $90.00$30.00 - $153.00$30.00 - $153.00Current price $30$30.00 - $153.00Current price $30 -
Customize your vitamin intake to support your specific health needs—especially if you have sensitivities—with Multivitamin One Sensitive!†
Multivitamin One Sensitive—A customizable multivitamin and mineral supplement. It is strategically formulated without certain nutrients to allow for individual serving size customization.†
ImprovedOriginal price $37 - Original price $222Original price $37 - Original price $222Original price $111$111$37.00 - $188.70Save 67%$37.00 - $188.70Original price $37.00 - Original price $222.00Original price $37.00 - Original price $222.00Original price $111.00$37.00 - $188.70$37.00 - $188.70Current price $37$37.00 - $188.70Current price $37 -
Foster healthy energy production and mood with methyl-free B Complex MF.†
B Complex MF—A potent B vitamin complex containing the 8 essential B vitamins, featuring non-methylated B12 and folate in the forms of Hydroxo B12 and folinic acid.†
Original price $32 - Original price $192Original price $32 - Original price $192Original price $96$96$32.00 - $163.20Save 67%$32.00 - $163.20Original price $32.00 - Original price $192.00Original price $32.00 - Original price $192.00Original price $96.00$32.00 - $163.20$32.00 - $163.20Current price $32$32.00 - $163.20Current price $32 -
Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Original price $23 - Original price $138Original price $23 - Original price $138Original price $69$69$23.00 - $117.30Save 67%$23.00 - $117.30Original price $23.00 - Original price $138.00Original price $23.00 - Original price $138.00Original price $69.00$23.00 - $117.30$23.00 - $117.30Current price $23$23.00 - $117.30Current price $23 -
Coming SoonOriginal price $45 - Original price $270Original price $45 - Original price $270Original price $135$135$45.00 - $229.50Save 67%$45.00 - $229.50Original price $45.00 - Original price $270.00Original price $45.00 - Original price $270.00Original price $135.00$45.00 - $229.50$45.00 - $229.50Current price $45$45.00 - $229.50Current price $45 -
Coming SoonOriginal price $29 - Original price $174Original price $29 - Original price $174Original price $87$87$29.00 - $147.90Save 67%$29.00 - $147.90Original price $29.00 - Original price $174.00Original price $29.00 - Original price $174.00Original price $87.00$29.00 - $147.90$29.00 - $147.90Current price $29$29.00 - $147.90Current price $29
-
Promote healthy energy production and mood without additional B12 and folate with B Minus.†
B Minus—A potent formula containing 6 essential B vitamins that’s free from B12 and folate to allow for customization of these two essential nutrients.†
Original price $32 - Original price $192Original price $32 - Original price $192Original price $96$96$32.00 - $163.20Save 67%$32.00 - $163.20Original price $32.00 - Original price $192.00Original price $32.00 - Original price $192.00Original price $96.00$32.00 - $163.20$32.00 - $163.20Current price $32$32.00 - $163.20Current price $32 -
Foster a healthy mood, motivation, learning, and memory with Dopamine Nutrients.†
Dopamine Nutrients—Designed to support healthy dopamine levels and the health of the cells that make it with key ingredients like L-Tyrosine, Ginkgo Biloba Extract, and Royal Jelly Concentrate.†
Sale
SaleBOGOOriginal price $49 - Original price $294Original price $49 - Original price $294Original price $147SALE $147$49.00 - $249.90Save 67%$49.00 - $249.90Original price $49.00 - Original price $294.00Original price $49.00 - Original price $294.00Original price $147.00$49.00 - $249.90$49.00 - $249.90Current price $49$49.00 - $249.90Current price $49 -
Prioritize your gut health with the comprehensive, nutrient-dense blend found in Gut Nutrients!†
Gut Nutrients—A blend of herbs and nutrients that synergistically supporting healthy digestion, GI barrier, and immune system function. L-Glutamine is added for enhanced gut lining support.†
Original price $50 - Original price $300Original price $50 - Original price $300Original price $150$150$50.00 - $255.00Save 67%$50.00 - $255.00Original price $50.00 - Original price $300.00Original price $50.00 - Original price $300.00Original price $150.00$50.00 - $255.00$50.00 - $255.00Current price $50$50.00 - $255.00Current price $50 -
Start your kids’ day off right with the bioavailable nutrients they need to keep going with Kids Multivitamin Chewable MF!†
Kids Multivitamin Chewable MF—A comprehensive multivitamin and multimineral with methyl-sensitive kids in mind in a great-tasting, kid-approved, and sugar-free chewable.†
ImprovedHSA / FSAOriginal price $30 - Original price $180Original price $30 - Original price $180Original price $90$90$30.00 - $153.00Save 67%$30.00 - $153.00Original price $30.00 - Original price $180.00Original price $30.00 - Original price $180.00Original price $90.00$30.00 - $153.00$30.00 - $153.00Current price $30$30.00 - $153.00Current price $30 -
Customize your vitamin intake to support your specific health needs—especially if you have sensitivities—with Multivitamin One Sensitive!†
Multivitamin One Sensitive—A customizable multivitamin and mineral supplement. It is strategically formulated without certain nutrients to allow for individual serving size customization.†
ImprovedOriginal price $37 - Original price $222Original price $37 - Original price $222Original price $111$111$37.00 - $188.70Save 67%$37.00 - $188.70Original price $37.00 - Original price $222.00Original price $37.00 - Original price $222.00Original price $111.00$37.00 - $188.70$37.00 - $188.70Current price $37$37.00 - $188.70Current price $37 -
Foster healthy energy production and mood with methyl-free B Complex MF.†
B Complex MF—A potent B vitamin complex containing the 8 essential B vitamins, featuring non-methylated B12 and folate in the forms of Hydroxo B12 and folinic acid.†
Original price $32 - Original price $192Original price $32 - Original price $192Original price $96$96$32.00 - $163.20Save 67%$32.00 - $163.20Original price $32.00 - Original price $192.00Original price $32.00 - Original price $192.00Original price $96.00$32.00 - $163.20$32.00 - $163.20Current price $32$32.00 - $163.20Current price $32 -
Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Original price $23 - Original price $138Original price $23 - Original price $138Original price $69$69$23.00 - $117.30Save 67%$23.00 - $117.30Original price $23.00 - Original price $138.00Original price $23.00 - Original price $138.00Original price $69.00$23.00 - $117.30$23.00 - $117.30Current price $23$23.00 - $117.30Current price $23 -
Coming SoonOriginal price $45 - Original price $270Original price $45 - Original price $270Original price $135$135$45.00 - $229.50Save 67%$45.00 - $229.50Original price $45.00 - Original price $270.00Original price $45.00 - Original price $270.00Original price $135.00$45.00 - $229.50$45.00 - $229.50Current price $45$45.00 - $229.50Current price $45 -
Coming SoonOriginal price $29 - Original price $174Original price $29 - Original price $174Original price $87$87$29.00 - $147.90Save 67%$29.00 - $147.90Original price $29.00 - Original price $174.00Original price $29.00 - Original price $174.00Original price $87.00$29.00 - $147.90$29.00 - $147.90Current price $29$29.00 - $147.90Current price $29
-
Promote healthy energy production and mood without additional B12 and folate with B Minus.†
B Minus—A potent formula containing 6 essential B vitamins that’s free from B12 and folate to allow for customization of these two essential nutrients.†
Original price $32 - Original price $192Original price $32 - Original price $192Original price $96$96$32.00 - $163.20Save 67%$32.00 - $163.20Original price $32.00 - Original price $192.00Original price $32.00 - Original price $192.00Original price $96.00$32.00 - $163.20$32.00 - $163.20Current price $32$32.00 - $163.20Current price $32 -
Foster a healthy mood, motivation, learning, and memory with Dopamine Nutrients.†
Dopamine Nutrients—Designed to support healthy dopamine levels and the health of the cells that make it with key ingredients like L-Tyrosine, Ginkgo Biloba Extract, and Royal Jelly Concentrate.†
Sale
SaleBOGOOriginal price $49 - Original price $294Original price $49 - Original price $294Original price $147SALE $147$49.00 - $249.90Save 67%$49.00 - $249.90Original price $49.00 - Original price $294.00Original price $49.00 - Original price $294.00Original price $147.00$49.00 - $249.90$49.00 - $249.90Current price $49$49.00 - $249.90Current price $49 -
Prioritize your gut health with the comprehensive, nutrient-dense blend found in Gut Nutrients!†
Gut Nutrients—A blend of herbs and nutrients that synergistically supporting healthy digestion, GI barrier, and immune system function. L-Glutamine is added for enhanced gut lining support.†
Original price $50 - Original price $300Original price $50 - Original price $300Original price $150$150$50.00 - $255.00Save 67%$50.00 - $255.00Original price $50.00 - Original price $300.00Original price $50.00 - Original price $300.00Original price $150.00$50.00 - $255.00$50.00 - $255.00Current price $50$50.00 - $255.00Current price $50 -
Start your kids’ day off right with the bioavailable nutrients they need to keep going with Kids Multivitamin Chewable MF!†
Kids Multivitamin Chewable MF—A comprehensive multivitamin and multimineral with methyl-sensitive kids in mind in a great-tasting, kid-approved, and sugar-free chewable.†
ImprovedHSA / FSAOriginal price $30 - Original price $180Original price $30 - Original price $180Original price $90$90$30.00 - $153.00Save 67%$30.00 - $153.00Original price $30.00 - Original price $180.00Original price $30.00 - Original price $180.00Original price $90.00$30.00 - $153.00$30.00 - $153.00Current price $30$30.00 - $153.00Current price $30 -
Customize your vitamin intake to support your specific health needs—especially if you have sensitivities—with Multivitamin One Sensitive!†
Multivitamin One Sensitive—A customizable multivitamin and mineral supplement. It is strategically formulated without certain nutrients to allow for individual serving size customization.†
ImprovedOriginal price $37 - Original price $222Original price $37 - Original price $222Original price $111$111$37.00 - $188.70Save 67%$37.00 - $188.70Original price $37.00 - Original price $222.00Original price $37.00 - Original price $222.00Original price $111.00$37.00 - $188.70$37.00 - $188.70Current price $37$37.00 - $188.70Current price $37 -
Foster healthy energy production and mood with methyl-free B Complex MF.†
B Complex MF—A potent B vitamin complex containing the 8 essential B vitamins, featuring non-methylated B12 and folate in the forms of Hydroxo B12 and folinic acid.†
Original price $32 - Original price $192Original price $32 - Original price $192Original price $96$96$32.00 - $163.20Save 67%$32.00 - $163.20Original price $32.00 - Original price $192.00Original price $32.00 - Original price $192.00Original price $96.00$32.00 - $163.20$32.00 - $163.20Current price $32$32.00 - $163.20Current price $32 -
Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Original price $23 - Original price $138Original price $23 - Original price $138Original price $69$69$23.00 - $117.30Save 67%$23.00 - $117.30Original price $23.00 - Original price $138.00Original price $23.00 - Original price $138.00Original price $69.00$23.00 - $117.30$23.00 - $117.30Current price $23$23.00 - $117.30Current price $23 -
Coming SoonOriginal price $45 - Original price $270Original price $45 - Original price $270Original price $135$135$45.00 - $229.50Save 67%$45.00 - $229.50Original price $45.00 - Original price $270.00Original price $45.00 - Original price $270.00Original price $135.00$45.00 - $229.50$45.00 - $229.50Current price $45$45.00 - $229.50Current price $45 -
Coming SoonOriginal price $29 - Original price $174Original price $29 - Original price $174Original price $87$87$29.00 - $147.90Save 67%$29.00 - $147.90Original price $29.00 - Original price $174.00Original price $29.00 - Original price $174.00Original price $87.00$29.00 - $147.90$29.00 - $147.90Current price $29$29.00 - $147.90Current price $29