Dirty Genes® - COMT Slow Support
The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. Slow COMT may lead to high estrogen or too many neurotransmitters (dopamine, norepinephrine, and epinephrine). This could make you feel irritable, tense, or unable to relax. You might not sleep well and you might even have detoxification or hormone problems.
The COMT gene makes an enzyme that regulates neurotransmitters and hormones. It plays a big role in how your body breaks down estrogen and uses other compounds. Slow COMT may lead to high estrogen or too many neurotransmitters (dopamine, norepinephrine, and epinephrine). This could make you feel irritable, tense, or unable to relax. You might not sleep well and you might even have detoxification or hormone problems.
Slow COMT activity may mean that you don’t have enough SAMe or too much homocysteine. Nutrients that support a balanced COMT gene include vitamin B12, other B vitamins, folate, and magnesium. Your MTHFR gene works closely with COMT, so you also need nutrients for methylation, like betaine and SAMe.
To support your slow COMT gene, you need supplementation that promotes the optimal way your gene should function. Hydrox-Adeno B12 and Folinic Acid provide bioavailable sources of vitamin B12 and folate in methyl-free versions, which might be easier to tolerate if you have a sensitive brain.
Explore other supportive nutrients for your COMT gene below, like Optimal Magnesium , Adrenal Support, or Optimal Sleep.
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Customize your vitamin intake to support your specific health needs—especially if you have sensitivities—with Multivitamin One Sensitive!†
Multivitamin One Sensitive—A customizable multivitamin and mineral supplement. It is strategically formulated without certain nutrients to allow for individual serving size customization.†
ImprovedMultivitamin One Sensitive
SHOP NOW $354.5Rated 4.5 out of 5 stars78 ReviewsFrom $35Key Benefits and Actions† Designed for sensitive individuals One-a-day multivitamin with chelated trace minerals Free from B12, Folate, Copper, ...
View full detailsOriginal price $35 - Original price $210Original price $35 - Original price $210Original price $105$105$35.00 - $178.50(Save 67%)$35.00 - $178.50Original price $35.00 - Original price $210.00Original price $35.00 - Original price $210.00Original price $105.00$35.00 - $178.50$35.00 - $178.50Current price $35$35.00 - $178.50Current price $35 -
Support normal liver and gut detoxification and healthy cholesterol and estrogen levels with Calcium D-Glucarate.†
Calcium D-Glucarate—Contains 250 mg of calcium D-glucarate, a form of glucaric acid that is stabilized with calcium to support your body’s healthy natural detoxification function.†
Calcium D-Glucarate
SHOP NOW $324.9Rated 4.9 out of 5 stars141 ReviewsFrom $32Key Benefits and Actions† Supports liver & gut detoxification Supports normal estrogen metabolism Supports normal cholesterol levels Who Ne...
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Get the high-strength, methyl-free prenatal you need to protect you and your baby’s health with Optimal Prenatal MF!†
Optimal Prenatal MF—The first non-methylated prenatal vitamin of its kind that includes bioavailable and well-tolerated sources of B12 and folate that are absolutely critical for prenatal health.†
ImprovedOptimal Prenatal MF
SHOP NOW $654.9Rated 4.9 out of 5 stars76 ReviewsFrom $65Provides comprehensive preconception, prenatal and postnatal nutrition with bioavailable, non-methylated forms of folate and B12 to support a heal...
View full detailsOriginal price $65 - Original price $390Original price $65 - Original price $390Original price $195$195$65.00 - $331.50(Save 67%)$65.00 - $331.50Original price $65.00 - Original price $390.00Original price $65.00 - Original price $390.00Original price $195.00$65.00 - $331.50$65.00 - $331.50Current price $65$65.00 - $331.50Current price $65 -
Help sustain healthy magnesium levels to support healthy sleep and feelings of relaxation and calm with Magnesium Plus†
Magnesium Plus—Provides two bioavailable forms of magnesium (malate and glycinate) plus the active form of vitamin B6 to enhance absorption in support of natural energy, relaxation, and GI comfort.†
Magnesium Plus
SHOP NOW $284.9Rated 4.9 out of 5 stars199 ReviewsFrom $28Key Benefits and Actions† Magnesium plus vitamin B6 for enhanced absorption and utilization Well-absorbed malate and glycinate forms of magnesiu...
View full detailsOriginal price $28 - Original price $168Original price $28 - Original price $168Original price $84$84$28.00 - $142.80(Save 67%)$28.00 - $142.80Original price $28.00 - Original price $168.00Original price $28.00 - Original price $168.00Original price $84.00$28.00 - $142.80$28.00 - $142.80Current price $28$28.00 - $142.80Current price $28 -
Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Magnesium Malate Powder
SHOP NOW $224.7Rated 4.7 out of 5 stars189 ReviewsFrom $22Key Benefits and Actions† Potent, powdered magnesium supplement Well-absorbed dimalate form of magnesium Supports healthy energy, muscles, nerve...
View full detailsOriginal price $22 - Original price $132Original price $22 - Original price $132Original price $66$66$22.00 - $112.20(Save 67%)$22.00 - $112.20Original price $22.00 - Original price $132.00Original price $22.00 - Original price $132.00Original price $66.00$22.00 - $112.20$22.00 - $112.20Current price $22$22.00 - $112.20Current price $22 -
Support a healthy lifestyle and balanced diet during pregnancy, especially if you’re methyl-sensitive with Prenatal Essentials MF.†
Prenatal Essentials MF—A concise yet powerful prenatal multivitamin. It supports methylation with bioavailable, methyl-free forms of key pregnancy nutrients.†
ImprovedPrenatal Essentials MF
SHOP NOW $355.0Rated 5.0 out of 5 stars111 ReviewsFrom $35Key Benefits and Actions† 2 capsule serving size provides your essential daily prenatal nutrients in methyl-free forms Supports healthy immune, ...
View full detailsOriginal price $35 - Original price $210Original price $35 - Original price $210Original price $105$105$35.00 - $178.50(Save 67%)$35.00 - $178.50Original price $35.00 - Original price $210.00Original price $35.00 - Original price $210.00Original price $105.00$35.00 - $178.50$35.00 - $178.50Current price $35$35.00 - $178.50Current price $35
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Customize your vitamin intake to support your specific health needs—especially if you have sensitivities—with Multivitamin One Sensitive!†
Multivitamin One Sensitive—A customizable multivitamin and mineral supplement. It is strategically formulated without certain nutrients to allow for individual serving size customization.†
ImprovedMultivitamin One Sensitive
SHOP NOW $354.5Rated 4.5 out of 5 stars78 ReviewsFrom $35Key Benefits and Actions† Designed for sensitive individuals One-a-day multivitamin with chelated trace minerals Free from B12, Folate, Copper, ...
View full detailsOriginal price $35 - Original price $210Original price $35 - Original price $210Original price $105$105$35.00 - $178.50(Save 67%)$35.00 - $178.50Original price $35.00 - Original price $210.00Original price $35.00 - Original price $210.00Original price $105.00$35.00 - $178.50$35.00 - $178.50Current price $35$35.00 - $178.50Current price $35 -
Support normal liver and gut detoxification and healthy cholesterol and estrogen levels with Calcium D-Glucarate.†
Calcium D-Glucarate—Contains 250 mg of calcium D-glucarate, a form of glucaric acid that is stabilized with calcium to support your body’s healthy natural detoxification function.†
Calcium D-Glucarate
SHOP NOW $324.9Rated 4.9 out of 5 stars141 ReviewsFrom $32Key Benefits and Actions† Supports liver & gut detoxification Supports normal estrogen metabolism Supports normal cholesterol levels Who Ne...
View full detailsOriginal price $32 - Original price $187.68Original price $32 - Original price $187.68Original price $95.04$95.04$32.00 - $163.20(Save 66%)$32.00 - $163.20Original price $32.00 - Original price $187.68Original price $32.00 - Original price $187.68Original price $95.04$32.00 - $163.20$32.00 - $163.20Current price $32$32.00 - $163.20Current price $32 -
Get the high-strength, methyl-free prenatal you need to protect you and your baby’s health with Optimal Prenatal MF!†
Optimal Prenatal MF—The first non-methylated prenatal vitamin of its kind that includes bioavailable and well-tolerated sources of B12 and folate that are absolutely critical for prenatal health.†
ImprovedOptimal Prenatal MF
SHOP NOW $654.9Rated 4.9 out of 5 stars76 ReviewsFrom $65Provides comprehensive preconception, prenatal and postnatal nutrition with bioavailable, non-methylated forms of folate and B12 to support a heal...
View full detailsOriginal price $65 - Original price $390Original price $65 - Original price $390Original price $195$195$65.00 - $331.50(Save 67%)$65.00 - $331.50Original price $65.00 - Original price $390.00Original price $65.00 - Original price $390.00Original price $195.00$65.00 - $331.50$65.00 - $331.50Current price $65$65.00 - $331.50Current price $65 -
Help sustain healthy magnesium levels to support healthy sleep and feelings of relaxation and calm with Magnesium Plus†
Magnesium Plus—Provides two bioavailable forms of magnesium (malate and glycinate) plus the active form of vitamin B6 to enhance absorption in support of natural energy, relaxation, and GI comfort.†
Magnesium Plus
SHOP NOW $284.9Rated 4.9 out of 5 stars199 ReviewsFrom $28Key Benefits and Actions† Magnesium plus vitamin B6 for enhanced absorption and utilization Well-absorbed malate and glycinate forms of magnesiu...
View full detailsOriginal price $28 - Original price $168Original price $28 - Original price $168Original price $84$84$28.00 - $142.80(Save 67%)$28.00 - $142.80Original price $28.00 - Original price $168.00Original price $28.00 - Original price $168.00Original price $84.00$28.00 - $142.80$28.00 - $142.80Current price $28$28.00 - $142.80Current price $28 -
Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Magnesium Malate Powder
SHOP NOW $224.7Rated 4.7 out of 5 stars189 ReviewsFrom $22Key Benefits and Actions† Potent, powdered magnesium supplement Well-absorbed dimalate form of magnesium Supports healthy energy, muscles, nerve...
View full detailsOriginal price $22 - Original price $132Original price $22 - Original price $132Original price $66$66$22.00 - $112.20(Save 67%)$22.00 - $112.20Original price $22.00 - Original price $132.00Original price $22.00 - Original price $132.00Original price $66.00$22.00 - $112.20$22.00 - $112.20Current price $22$22.00 - $112.20Current price $22 -
Support a healthy lifestyle and balanced diet during pregnancy, especially if you’re methyl-sensitive with Prenatal Essentials MF.†
Prenatal Essentials MF—A concise yet powerful prenatal multivitamin. It supports methylation with bioavailable, methyl-free forms of key pregnancy nutrients.†
ImprovedPrenatal Essentials MF
SHOP NOW $355.0Rated 5.0 out of 5 stars111 ReviewsFrom $35Key Benefits and Actions† 2 capsule serving size provides your essential daily prenatal nutrients in methyl-free forms Supports healthy immune, ...
View full detailsOriginal price $35 - Original price $210Original price $35 - Original price $210Original price $105$105$35.00 - $178.50(Save 67%)$35.00 - $178.50Original price $35.00 - Original price $210.00Original price $35.00 - Original price $210.00Original price $105.00$35.00 - $178.50$35.00 - $178.50Current price $35$35.00 - $178.50Current price $35
-
Customize your vitamin intake to support your specific health needs—especially if you have sensitivities—with Multivitamin One Sensitive!†
Multivitamin One Sensitive—A customizable multivitamin and mineral supplement. It is strategically formulated without certain nutrients to allow for individual serving size customization.†
ImprovedMultivitamin One Sensitive
SHOP NOW $354.5Rated 4.5 out of 5 stars78 ReviewsFrom $35Key Benefits and Actions† Designed for sensitive individuals One-a-day multivitamin with chelated trace minerals Free from B12, Folate, Copper, ...
View full detailsOriginal price $35 - Original price $210Original price $35 - Original price $210Original price $105$105$35.00 - $178.50(Save 67%)$35.00 - $178.50Original price $35.00 - Original price $210.00Original price $35.00 - Original price $210.00Original price $105.00$35.00 - $178.50$35.00 - $178.50Current price $35$35.00 - $178.50Current price $35 -
Support normal liver and gut detoxification and healthy cholesterol and estrogen levels with Calcium D-Glucarate.†
Calcium D-Glucarate—Contains 250 mg of calcium D-glucarate, a form of glucaric acid that is stabilized with calcium to support your body’s healthy natural detoxification function.†
Calcium D-Glucarate
SHOP NOW $324.9Rated 4.9 out of 5 stars141 ReviewsFrom $32Key Benefits and Actions† Supports liver & gut detoxification Supports normal estrogen metabolism Supports normal cholesterol levels Who Ne...
View full detailsOriginal price $32 - Original price $187.68Original price $32 - Original price $187.68Original price $95.04$95.04$32.00 - $163.20(Save 66%)$32.00 - $163.20Original price $32.00 - Original price $187.68Original price $32.00 - Original price $187.68Original price $95.04$32.00 - $163.20$32.00 - $163.20Current price $32$32.00 - $163.20Current price $32 -
Get the high-strength, methyl-free prenatal you need to protect you and your baby’s health with Optimal Prenatal MF!†
Optimal Prenatal MF—The first non-methylated prenatal vitamin of its kind that includes bioavailable and well-tolerated sources of B12 and folate that are absolutely critical for prenatal health.†
ImprovedOptimal Prenatal MF
SHOP NOW $654.9Rated 4.9 out of 5 stars76 ReviewsFrom $65Provides comprehensive preconception, prenatal and postnatal nutrition with bioavailable, non-methylated forms of folate and B12 to support a heal...
View full detailsOriginal price $65 - Original price $390Original price $65 - Original price $390Original price $195$195$65.00 - $331.50(Save 67%)$65.00 - $331.50Original price $65.00 - Original price $390.00Original price $65.00 - Original price $390.00Original price $195.00$65.00 - $331.50$65.00 - $331.50Current price $65$65.00 - $331.50Current price $65 -
Help sustain healthy magnesium levels to support healthy sleep and feelings of relaxation and calm with Magnesium Plus†
Magnesium Plus—Provides two bioavailable forms of magnesium (malate and glycinate) plus the active form of vitamin B6 to enhance absorption in support of natural energy, relaxation, and GI comfort.†
Magnesium Plus
SHOP NOW $284.9Rated 4.9 out of 5 stars199 ReviewsFrom $28Key Benefits and Actions† Magnesium plus vitamin B6 for enhanced absorption and utilization Well-absorbed malate and glycinate forms of magnesiu...
View full detailsOriginal price $28 - Original price $168Original price $28 - Original price $168Original price $84$84$28.00 - $142.80(Save 67%)$28.00 - $142.80Original price $28.00 - Original price $168.00Original price $28.00 - Original price $168.00Original price $84.00$28.00 - $142.80$28.00 - $142.80Current price $28$28.00 - $142.80Current price $28 -
Support healthy magnesium levels for your hormones, energy, bones, blood sugar, mood, and muscles with Magnesium Malate Powder!†
Magnesium Malate Powder—A potent 500 mg serving of dimagnesium malate, a well-tolerated form of magnesium that binds to malate for superior absorption and energy support.†
Magnesium Malate Powder
SHOP NOW $224.7Rated 4.7 out of 5 stars189 ReviewsFrom $22Key Benefits and Actions† Potent, powdered magnesium supplement Well-absorbed dimalate form of magnesium Supports healthy energy, muscles, nerve...
View full detailsOriginal price $22 - Original price $132Original price $22 - Original price $132Original price $66$66$22.00 - $112.20(Save 67%)$22.00 - $112.20Original price $22.00 - Original price $132.00Original price $22.00 - Original price $132.00Original price $66.00$22.00 - $112.20$22.00 - $112.20Current price $22$22.00 - $112.20Current price $22 -
Support a healthy lifestyle and balanced diet during pregnancy, especially if you’re methyl-sensitive with Prenatal Essentials MF.†
Prenatal Essentials MF—A concise yet powerful prenatal multivitamin. It supports methylation with bioavailable, methyl-free forms of key pregnancy nutrients.†
ImprovedPrenatal Essentials MF
SHOP NOW $355.0Rated 5.0 out of 5 stars111 ReviewsFrom $35Key Benefits and Actions† 2 capsule serving size provides your essential daily prenatal nutrients in methyl-free forms Supports healthy immune, ...
View full detailsOriginal price $35 - Original price $210Original price $35 - Original price $210Original price $105$105$35.00 - $178.50(Save 67%)$35.00 - $178.50Original price $35.00 - Original price $210.00Original price $35.00 - Original price $210.00Original price $105.00$35.00 - $178.50$35.00 - $178.50Current price $35$35.00 - $178.50Current price $35
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