L-Methylfolate Supplements
L-methylfolate is the most abundant form of folate in your body. It is also referred to as active folate or L-5-MTHF. Other types of folate need to be converted into active forms. People with MTHFR gene variants may not be able to activate folic acid. If you are low on this critical nutrient, your methylation cycle won’t work effectively.
Methylation is essential for regulating gene expression and controlling how your DNA works. L-methylfolate supports healthy red blood cells, mental health, and normal homocysteine levels.
L-methylfolate is the most abundant form of folate in your body. It is also referred to as active folate or L-5-MTHF. Other types of folate need to be converted into active forms. People with MTHFR gene variants may not be able to activate folic acid. If you are low on this critical nutrient, your methylation cycle won’t work effectively.
Methylation is essential for regulating gene expression and controlling how your DNA works. L-methylfolate supports healthy red blood cells, mental health, and normal homocysteine levels. It is found in foods like leafy greens and liver. If you aren’t eating a lot of these, you may benefit from a dietary supplement to support healthy folate levels.†
Seeking Health’s L-methylfolate supplements include L-5-MTHF and Active B12 with L-5-MTHF. You can also get Optimal Prenatal and Optimal Multivitamin, which provide folate along with active vitamin B12 (methylcobalamin), calcium, and other important vitamins and minerals.
Check out this Folate Comparison Chart to select the right folate for you.
Explore L-methylfolate supplementation options below.
If you find that methylated supplements make you feel jittery or upset, use this comparison chart to learn about the differences between methylated and non-methylated products or check out this article.
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Best SellerOptimal Prenatal - 240 Capsules
4.8Rated 4.8 out of 5686 Reviews Based on 686 reviewsFrom $59.95Optimal Prenatal capsules by Seeking Health provide a comprehensive prenatal formula with a unique blend of amino acids, chelated minerals, and vit...
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Best SellerHomocysteX Plus - 60 Capsules
4.9Rated 4.9 out of 5191 Reviews Based on 191 reviewsFrom $32.95HomocysteX Plus by Seeking Health supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TM...
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Best SellerBonus RewardsMultivitamin One - 45 Vegetarian Capsules
4.9Rated 4.9 out of 5239 Reviews Based on 239 reviewsFrom $32.95Multivitamin One by Seeking Health provides a wide variety of nutrients in well-absorbed or active forms in a convenient capsule format. Unlike our...
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Best SellerBonus RewardsB Complex Plus - 100 Capsules
4.9Rated 4.9 out of 5249 Reviews Based on 249 reviewsFrom $27.95B Complex Plus by Seeking Health provides eight B vitamins with active forms of folate, vitamin B12, riboflavin, and B6. This complex also contains...
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Best SellerMix & Match
Buy 1, Get 2 FREE*Optimal Multivitamin - 240 Capsules
4.9Rated 4.9 out of 5236 Reviews Based on 236 reviewsFrom $59.95Optimal Multivitamin by Seeking Health is a complete daily multivitamin and mineral supplement containing more than 50 nutritional ingredients, all...
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New NameKids Multivitamin - 180 Capsules
4.8Rated 4.8 out of 5147 Reviews Based on 147 reviewsFrom $32.95Kids Multivitamin by Seeking Health is a comprehensive multivitamin and mineral supplement that is specifically designed to support the nutritional...
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L-5-MTHF (1700 mcg DFE) - 60 Capsules
4.9Rated 4.9 out of 568 Reviews Based on 68 reviewsFrom $17.95L-5-MTHF Capsules by Seeking Health provide 1,700 mcg DFE (1,000 mcg) of pure non-racemic L-methylfolate, an active coenzyme form of folate. Folate...
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Buy 1, Get 2 FREE*Optimal Multivitamin Plus - 240 Capsules
4.9Rated 4.9 out of 574 Reviews Based on 74 reviewsFrom $72.95Optimal Multivitamin Plus by Seeking Health is a complete natural daily multivitamin and mineral supplement with active B vitamins and L-5-MTHF. Op...
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Prenatal Essentials - 60 Capsules
4.9Rated 4.9 out of 5124 Reviews Based on 124 reviewsFrom $32.95Do you need a prenatal supplement without an overload of excess nutrients? Are you a pregnant mother already eating a healthy, well-balanced diet? ...
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Bonus RewardsMultivitamin with Iron - 120 Capsules
4.8Rated 4.8 out of 580 Reviews Based on 80 reviewsFrom $32.95Multivitamin with Iron by Seeking Health is a well-rounded daily multivitamin and mineral supplement with high-potency gentle iron and active B vit...
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Buy 1, Get 2 FREE*Optimal Man - 120 Capsules
4.8Rated 4.8 out of 539 Reviews Based on 39 reviewsFrom $59.95As a father, your genetics are passed along to your child, as you may well know. But did you know that your genes can change expression based on yo...
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Claire C.

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Keeps me hydrated so I can avoid breaking my fast until lunch time! I love the fizziness of the seltzer flavor.

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Best probiotic for women
I love this probiotic. I often get flora imbalances since having my third child. I have been using this for 4 months a few times per week, and have had no issues since.