†Restrictions apply (see details)
Login or create an account to earn points.

HomocysteX Plus

60 Capsules

Key Benefits and Actions*

  • Provides active B vitamins in potent doses
  • May help support healthy methylation processes
  • May help support normal homocysteine conversion
  • May help support cognitive health

Ships tomorrow if ordered in the next 19 hours and 11 minutes!

Rewards Members will receive 200 Points for reviewing this product upon approval.

Availability: In stock

Learn more about our Autoship Program!

Full 30-Day Returns, Guaranteed.

Our return policy covers full refunds or replacements on items within 30 days of purchase.


Suitable for Vegans and Vegetarians

Free of:

Dairy, Egg, Fish, Shellfish, Tree Nuts, Peanuts, Wheat, Soy, Gluten, GMO

HomocysteX Plus by Seeking Health supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TMG) to synergistically support methylation processes and normal homocysteine metabolism. The body's methylation process is vital for formation of essential cell components such as proteins, nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes. By transferring methyl groups (three hydrogen atoms bonded to a carbon atom, known as CH3) from one molecule to another, methylation turns on genes, activates enzymes, drives detoxification reactions, influences hormone secretion, and helps maintain normal metabolism of homocysteine, a potentially harmful amino acid metabolite. Unfortunately, poor nutrition, oxidative stress, infections, metabolic defects, and various other factors can impair methylation processes throughout the body.*

To nutritionally support optimal methylation capacity, this product supplies folate, vitamin B12, B6, B2, and betaine in amounts and forms that are efficiently utilized and well-tolerated by the body. Taking just L-5-methylfolate is often times not sufficient for those with MTHFR mutations. Dr. Lynch provides these other ingredients, such as betaine (TMG), to help support healthy homocysteine levels and support the methylation cycle.*

Betaine is a powerful and important methyl donor for the body, especially for those who have MTHFR mutations. Vitamin B12 is crucial to the formation of healthy red blood cells, energy production, nervous system support, cognitive function, and homocysteine regulation. Vitamin B6 as P-5-P is important as a coenzyme for the normal metabolism of amino acids, carbohydrates and lipids. It is also involved in healthy cognitive development, immune health and homocysteine conversion. Riboflavin is important for body growth and red blood cell production and assists in the process of releasing energy from carbohydrates.*

For a methylation support supplement without the betaine, consider our HomocysteX. For a B12- and folate-only product, consider our Active B12 with L-5-MTHF or our Optimal Liposomal Active B12 with L-5-MTHF.

Suggested Use

Take 1 capsule daily after breakfast, or as directed by your healthcare professional.


Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged. Consult with a healthcare professional before use if you are using antibiotics or other medications.

Serving Size: 1 Capsule
Servings Per Container: 60

Supplement Facts

Riboflavin (as riboflavin-5’-phosphate sodium) 25 mg 1923%
Vitamin B6 (as pyridoxal-5’-phosphate) 15 mg 882%
Folate (as Quatrefolic (6S)-5-methyltetrahydrofolate, glucosamine salt) 800 mcg DFE 200%
Vitamin B12 (50% as methylcobalamin and 50% as adenosylcobalamin) 1000 mcg 41667%
TMG (trimethylglycine) 700 mg **
% DV (Daily Value) based on standard 2,000 calorie daily intake
**Daily Value not established

Other Ingredients: HPMC (capsule), ascorbyl palmitate, silica, and medium chain triglycerides.

Additional Info
Additional Info
Learning Center Find product FAQ and more! Click here.
Cost Per Serving $0.47
Delivery Method Vegetarian Capsule
Capsule Size 0
Storage Keep closed in a cool, dry place out of reach by children.
Age Suitability Adult
Manufactured In USA
Case Quantity 24
Dimensions (in.) Length: 2 / Width: 2 / Height: 3.75
Weight (lb.) 0.2000
Barcode 700580723534
Return Policy 30 Day Returns ― Learn more about our Return Policy.
Customer Reviews (89)
Could definitely see IMMEDIATE changes in my energy level! I was hesitant taking it on an empty stomach first thing in the morning, but I've had no problems with nausea. HomocysteX, where have you been all my life?! Review by Helen (Posted on 4/17/2012)
Wonderful Product!
My two children and I have MTHFR and have been using Metanx. I purchased HomeosysteX Plus and L-5-MTHF 1000 to replace Metanx. Very pleased with the results. Feel like it does a better job than Metanx. Review by Jeannie (Posted on 4/17/2012)
Thank you Dr. Lynch
I took a bottle of HomocysteX to my doctor's appt. My doctor looked at the ingredients with interest. He was very impressed with the ingredient list of HomocysteX Plus. I so appreciate this supplement,
there is nothing else like it.

# 167676
Review by SuzieQ (Posted on 4/17/2012)
Great Product
Our family has been on a variety of prescription Metafolate. I was a bit confused to see the fillers and artificial colors in these products. My understanding is that Metafolate can help people with the MTHFR gene detox. It made sense to me to avoid things that hindered detoxing. I so appreciate Homocystex! It contains what I need without artificial fillers or colors.

Order # 164778
Review by tobysmom (Posted on 4/17/2012)
Not Good for People with Reynauds
I am homozygous for MTHFR so i thought this would be an excellent product for me. In addition to the MTHFR problem i also suffer from Reynaud's syndrome. I am very careful about cold exposure and have very few bouts normally. Once I started taking the Homocystex, I started having bouts in both my hands and feet several times a day. I RARELY get them in my feet. I stopped the Homocystex and immediately the bouts stopped, but once i tried taking the Homocystex again they returned. Unfortunately I wasted $27.95 to find out. I hope my experience can help someone else. I will be going back to high doses of Folinic acid (Leucovorin), which helped with my energy level and did not bring on Reynaud's issues. I wish this product had worked for me:(

Order # 100018392

Sorry to hear that HomocysteX did not work well for you. HomocysteX is a potent product - and when used by people having the right biochemistry - works amazingly well.

Some people - especially those homozygous A1298C - do not seem to do well with HomocysteX. This is likely because they are already methylating fairly well but not getting enough BH4. Having worked with many with A1298C, I have found that HomocysteX does not work well for them. This is not a blanket statement as there are life circumstances, other mutations and environmental factor in play which cause a variation from person to person and this causes some things to work well for some and not for others.

Raynauds tends to do well with increased niacin, magnesium, stress relievers, contrast hot/cold therapy, healing the gut, vitamin D3 to name a few.

For people who are already over methylated, HomocysteX is not for them. A good way to see if you are over methylated is to check your histamine levels. Low histamine = overmethylated according to Dr Pfeiifer.
Review by jusmeamom (Posted on 4/17/2012)
Great Product!
This is a very complete product. I have been taking only B-12 and Folic Acid in the methyl forms. I did not realize how important it is to have B-6 and the other ingredients in this product. It makes a world of difference in the way it makes me feel. Thanks for all the great information as well.

Order # 155418
Review by Lynn (Posted on 4/17/2012)
Pregnant after 4 chemical pregnancies
After having 4 chemical pregnancies I found out I'm homozygous C677t. I started taking this in addition to my prenatal and fish oil supplements and I'm now 5 weeks pregnant. I think the active folic acid may have made this possible. I'm now trying to find a prenatal with L-5-MTHF but will continue to take this following my pregnancy. Review by Lis (Posted on 4/17/2012)
could not tolerate B's
This is the first B complex I have ever been able to take successfully! It is greatly enchancing my overall health. I have immune system issues that are finally turning around. Recently my family all came down with a servere form of pneumonia. I was able to take care of them and never got sick! This is a personal first. Review by nana (Posted on 2/3/2012)
I have been using this to treat my depression and have noticed a change for the better in my mood. I highly recommend. Review by Darla (Posted on 11/28/2011)

Items 81 to 89 of 89 total

per page
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Write Your Own Review

Only registered users can write reviews. Please, log in or register

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

You may also be interested in the following product(s)
Optimal Curcumin Optimal Curcumin
28 Review(s)
Niacin Niacin
14 Review(s)

You demand the best for you and your family. We research so we can give it to you. Our rapid growth is a testament to you, our customers.
Seeking Health is a proud honoree of Inc. 5000’s fastest-growing companies in America for the third year in a row.

NSF GMP Registered
BBB Accredited