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P-5-P (Pyridoxal 5-Phosphate)

  • Active, bioavailable form of vitamin B6
  • Homocysteine metabolism support
  • Supports a healthy mood

Who Needs P-5-P (Pyridoxal 5-Phosphate)

Vitamin B6 is an essential nutrient that supports numerous functions in your body. It’s needed to metabolize homocysteine, normalize mood, balance hormones, and help you sleep.

Vitamin B6 deficiency has been associated with problems involving the menstrual cycle, heart health, and mood.

Unfortunately, many people have trouble converting food sources of vitamin B6 into its active form, known as pyridoxal 5’-phosphate or P-5-P. These individuals may benefit from P-5-P dietary supplements.

Seeking Health’s P-5-P contains a potent 25 mg of vitamin B6 (1,471% Daily Value) in the active form of P-5-P (pyridoxal 5’-phosphate).

This high-strength vitamin B6 supplement is gluten-free and ideal for those who are deficient or require higher amounts. It can be a great boost to your daily multivitamin or B-complex supplement.

P-5-P (pyridoxal 5’-phosphate) is considered by many to be the best vitamin B6 form. Vitamin B6 (or pyridoxine) must have a phosphate group attached for it to bind to enzymes. P-5-P is considered an active coenzyme form of vitamin B6. It activates over 140 different enzymatic reactions in the body. Like the other B complex vitamins, you must obtain this water-soluble vitamin daily from food. This is because your body does not make it.

Vitamin B6 is required for healthy:

  • Breakdown of amino acids, carbohydrates, and fats
  • Energy production/energy metabolism
  • Immune system function
  • Brain function
  • Central nervous system function
  • Red blood cells and red blood cell function
  • Methylation processes
  • Many enzymatic reactions

P-5-P pairs well with magnesium to promote healthy female menstrual cycles, neurotransmitter function, and hormone metabolism prior to menstruation. It may also support stomach comfort and digestion due to occasional nausea or morning sickness.

It can be challenging to get enough vitamin B6 from foods alone. Seeking Health’s P-5-P delivers a high-quality form of vitamin B6 in a convenient capsule. For a complete B complex containing active forms of folate and vitamin B12, consider B Complex Plus.

Customer Review

recommended by my doc

I take vitamin B individually because I can't seem to take any B complex especially B12. Thanks to Seeking Health. I take this to supplement one of the Vitamin B group. ~Junghun Y.

Key Ingredients In P-5-P (Pyridoxal 5-Phosphate)

  • P-5-P (pyridoxal-5’-phosphate): The active, readily available coenzyme form of vitamin B6 plays a role in neurotransmitter metabolism and supporting a healthy mood. P-5-P also supports the healthy metabolism of hormones, homocysteine, sulfur, amino acids, and over 140 different enzymatic reactions in the body.

Why P-5-P (Pyridoxal 5-Phosphate) Works

Foods are a primary source of vitamin B6 or pyridoxine. Healthy colonies of gut microbes also produce a large percentage of our daily requirements for pyridoxine.

Pyridoxine must be transformed into pyridoxal-5-phosphate (P-5-P) before it can bind to enzymes and carry out a host of biochemical reactions in the human body. The enzyme that facilitates the final step of the transformation into P-5-P is known as pyridoxal kinase. Since ATP (energy) is needed for this enzyme to function, insufficient levels of ATP or energy may lead to lower P-5-P formation. Genetic variations may also slow this enzyme. If a person has both slow enzyme function and low ATP levels, their formation of P-5-P may be challenged. These individuals may benefit from a pyridoxal-5-phosphate supplement.

The active form of vitamin B6, P-5-P, is used as a coenzyme in over 140 chemical reactions. These include enzymes that facilitate detoxification, neurotransmitter function, hormone metabolism and signaling, and much more.

One of the most well-known enzymes supported by P-5-P is the CBS enzyme. This facilitates the conversion of homocysteine into cysteine that is used for making glutathione.

Lesser known is the fact that P-5-P plays a role in the AADC enzyme. The Aromatic Acid Decarboxylase enzyme regulates the production of both dopamine and serotonin. These are considered the “feel good” neurotransmitters that support a healthy mood.

While only two examples out of 140 are mentioned here, the importance of maintaining healthy levels of P-5-P cannot be understated!

P-5-P (Pyridoxal 5-Phosphate)
Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 100

Vitamin B6 (as pyridoxal 5'-phosphate) 25 mg 1471%
% DV (Daily Value) based on standard 2,000 calorie daily intake
**Daily Value not established

Other Ingredients: Microcrystalline cellulose, HPMC (capsule), ascorbyl palmitate, and silica.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Capsules
  • How To Store: Keep closed in a cool, dry place out of reach of children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives

How to Use P-5-P (Pyridoxal 5-Phosphate)

Suggested Use

Take 1 capsule daily with food or as directed by your healthcare provider.


Children and breastfeeding or pregnant women should consult their healthcare professional prior to use. Do not use if tamper seal is damaged.

FAQs for P-5-P (Pyridoxal 5-Phosphate)

What is the purpose of each ingredient in P-5-P?

Ingredients Purpose
Vitamin B6 (as pyridoxal 5'-phosphate) Supports healthy metabolism of homocysteine, glutathione, protein and amino acids, and neurotransmitters

Who is P-5-P intended for?

P-5-P is intended for those seeking an "active" or "coenzyme" form of vitamin B6 in a potent dose. Vitamin B6 ( P-5-P) is needed for more than 140 enzyme reactions in the body, including healthy hormone balance, mood, and methylation. It also supports healthy homocysteine metabolism and healthy levels of homocysteine, which are thought to support cardiovascular health.

Those who eat a mostly vegan or vegetarian diet may be at increased risk for deficiency. B6 supplementation may be important for these individuals.

How to use P-5-P?

Take 1 capsule daily with food or as directed by your healthcare professional.

If you struggle to swallow vitamin supplements in capsule form, the capsules may be pulled apart and sprinkled on food or in juice.

If you have a question that's not addressed
here, see all frequently asked questions.


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What our customers say

Real reviews from real customers.

Rated 4.9 out of 5 stars
Based on 97 reviews
Total 5 star reviews: 89 Total 4 star reviews: 7 Total 3 star reviews: 0 Total 2 star reviews: 0 Total 1 star reviews: 1
99%would recommend this product
97 reviews
  • MS
    Melissa S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    13 hours ago
    Sleep and dream aid

    Helps me sleep, and gives me more pleasant dreams. Also helps with histamine issues. This is an excellent product.

  • JG
    Jordan G.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    3 months ago
    Repurchased again and again

    I continue to repurchase this p-5-p time and again! Very affordable.

  • NA
    Nikki A.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    3 months ago
    Need my b6!

    I trust Seeking Health and love the additional education and information each product provides. I take 2 each day!!!

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These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.