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Hydroxo B12

  • Most stable form of methyl-free B12
  • Powerful energy and methylation support
  • Supports healthy detoxification

Who Needs Hydroxo B12

>Are you sensitive to methyl B12 products?

Are you exposed to toxins such as smoke and other air pollutants?

Vitamin B12 is well known for its ability to support energy production. A specific form of B12 called hydroxocobalamin (hydroxo B12) plays a unique role in maintaining healthy detoxification pathways. In addition, this methyl-free B12 is excellent for those sensitive to methyl groups.

Hydroxo B12 by Seeking Health contains 2,000 mcg of hydroxocobalamin in an well-digested lozenge.

As the most stable form of vitamin B12, hydroxocobalamin appears to circulate longer in the human body than all other forms. ‘Hydroxo’ B12 can easily convert to both ‘adeno’ and ‘methyl’ forms to support healthy methylation, detoxification, and energy production.

Due to its shape, hydroxo B12 supports the normal detoxification of toxins present in environmental exposures, such as smoke inhalation and other pollutants. While nitric oxide is vital for blood flow, high levels may contribute to headaches and migraines. Hydroxocobalamin may help to support balanced nitric oxide levels in the body.

Vitamin B12 deficiency is common. It is one of the most difficult nutrients for your body to absorb and utilize. Vitamin B12 deficiency can be characterized by fatigue, memory issues, and tingling in your toes or fingers.

Causes of vitamin B12 deficiency can include:

  • Malabsorption
  • Low stomach acid
  • Vegetarian or vegan diet
  • Insufficient intrinsic factor
  • Slowed transcobalamin enzymes

It’s critical to consume B12 in a bioavailable form that your body can readily utilize. Ideally, B12 is in a format designed for optimal digestion, absorption, and utilization, such as a lozenge. If you’re sensitive to methylated nutrients, you also want a supplement free of methyl groups.

Hydroxo B12 provides bioavailable, methyl-free B12 in a delicious lozenge for fast-acting support.

Hydroxo B12 supports healthy:

  • Methylation processes
  • Energy production
  • Detoxification
  • Homocysteine levels
  • Sensitivity to methyl groups

With this potent and delicious vitamin B12 supplement, optimal energy has never been easier!

Customer Review

Finally, A B12 my body likes!

I have tried a few different brands of methylcobalamin which is the form that has always been recommended to me. I have never muscle tested well for them. My numbers have been high as well. This one has been great. Muscle test for it and my body is happy. I don't need my adrenal support any more. Yea! ~Marilyn

Key Ingredients In Hydroxo B12

  • Hydroxocobalamin: A non-methylated form of B12 that quickly converts to adeno B12 and methyl B12 in the body. It supports healthy energy production and helps the body to utilize folate for methylation processes. Hydroxo B12 also supports the normal detoxification of toxins present in environmental exposures, such as smoke and other pollutants.

Why Hydroxo B12 Works

Hydroxocobalamin (Hydroxo B12) is a unique substance. Due to its shape, it can readily bind to certain compounds.

Nitric oxide is known as a beneficial substance that relaxes blood vessels and lowers blood pressure. However, it is possible to have too much of a good thing. When there is excess nitric oxide in your body, a harmful compound called peroxynitrite can form and cause cellular damage. Hydroxocobalamin appears to assist in the processing of excessive nitric oxide. This may help cells to maintain healthy nitric oxide levels.

Exposure to certain metal polishing chemicals, insecticides, and smoke from house fires can cause cyanide levels to go beyond healthy ranges. Most dietary supplements contain B12 as cyanocobalamin. Before it can be used, your liver must first convert cyanocobalamin into an active form and discard the cyanide. An alternative form of B12 such as hydroxocobalamin may be a healthier option.

Here at Seeking Health, you’ll never find the cyanide-containing form, cyanocobalamin, which requires extra steps for utilization in the body. Instead, you’ll only find bioavailable forms of vitamin B12 that your body can quickly recognize and utilize.

Hydroxocobalamin is known as one of the most stable forms of B12. It appears to circulate longer in the human body than all other forms. Hydroxo B12 can readily convert into cobalamin that your body uses to make both methylcobalamin and adenosylcobalamin.

Because of its versatile shape, hydroxocobalamin indirectly supports many critical processes. These include healthy homocysteine breakdown, MTR genetic variations, and methylation processes. Those with MTHFR gene variants may benefit from additional B12 support.

By converting to cobalamin, Hydroxo B12 also supports energy production. Cobalamin is readily converted to adenosylcobalamin in the mitochondria. Here it is used to facilitate ATP (energy) production.

Some people experience adverse reactions to methylated nutrients. These can include nervousness, headaches, or rapid heartbeat after taking methylcobalamin or methylfolate. Hydroxo B12 is free from methyl groups while still providing potent and fast-acting B12.

Support healthy B12 levels and detoxification (without the side effects of methyl groups!) with Hydroxo B12.

Hydroxo B12
Supplement Facts

Serving Size: 1 Lozenge
Servings Per Container: 60

Vitamin B12 (as hydroxocobalamin acetate) 2,000 mcg 83,333%
DV = Daily Value

Other Ingredients: Xylitol, ascorbyl palmitate, natural cherry flavor, malic acid, and silica.

  • Suitable For: Vegetarians and Vegans
  • Delivery Method: Lozenges
  • How To Store: Keep closed in a cool, dry place out of reach of children.

Free Of: Dairy, Eggs, Fish, Gluten, GMO, Peanuts, Sesame, Shellfish, Soy, Tree Nuts, Wheat, and Artificial Preservatives

How to Use Hydroxo B12

Suggested Use

Initial use for the first week, take ½ a lozenge by mouth, let dissolve slowly, then swallow. If needing more support, increase to 1 full lozenge. Take as needed. Do not take within 5 hours of bedtime as it may interfere with sleep. Use as directed by your healthcare professional.


Consult with your healthcare provider prior to use. Do not use if inner tamper seal is damaged.

Suitable for


Delivery Method


How to Store

Keep closed in a cool, dry place out of reach by children.

FAQs for Hydroxo B12

What is the purpose of each ingredient in Hydroxo B12?

Ingredients Purpose
Vitamin B12 (as hydroxocobalamin) Non-methylated form of B12; Quickly converts to methyl B12 in the body; Targets energy production and helps utilize folate for methylation processes; Supports the normal detoxification of toxins present in environmental exposures, such as smoke inhalation and other pollutants

Who is Hydroxo B12 intended for?

Hydroxo B12 is for individuals seeking a potent, non-methylated vitamin B12 supplement. This methyl-free form readily converts to methylcobalamin, the active coenzyme form of B12. It includes no methyl groups for those who are sensitive.

Hydroxo B12 also plays a role in the regulation of normal and healthy levels of both nitric oxide and cyanide. detoxification of nitric oxide and cyanide.

Which Vitamin B12 is right for me?

Check out this Vitamin B12 Supplement Comparison Chart.

This article will help you determine if you need a methyl-free supplement.

If you have a question that's not addressed
here, see all frequently asked questions.


Do you have Questions
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What our customers say

Real reviews from real customers.

Rated 4.8 out of 5 stars
Based on 174 reviews
Total 5 star reviews: 155 Total 4 star reviews: 10 Total 3 star reviews: 5 Total 2 star reviews: 1 Total 1 star reviews: 3
95%would recommend this product
174 reviews
  • HM
    Heather M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    3 weeks ago
    chewable and effective

    I like being able to chew them instead of having to swallow them whole. Seems to work!

  • N
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Feeling great!

    Since taking the Hydroxo B12 I have been feeling great! I also take the B Minus free of B12 and folate and Folinic Acid. My mood feels great for the most part! I have a lot of energy too.

  • SN
    Staci N.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 months ago
    The only B12 I can take!

    Hydroxo B12 is the only B12 that works for me!

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