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MTHFR Support Bundle

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Methyl B12 with L-Methylfolate
901 Reviews

Methyl B12 with L-Methylfolate
Optimal Electrolyte Strawberry Watermelon Container | Strawberry Watermelon / 1 Pack, Strawberry Watermelon / 3 Pack, Strawberry Watermelon / 6 Pack
1702 Reviews

Optimal Electrolyte
Riboflavin Supplement Bottle
126 Reviews

Riboflavin

MTHFR Support Bundle

You have an MTHFR variant. Here’s your starting point.

If you’re new here, this bundle was made for you.

Figuring out what to take for MTHFR can feel overwhelming. Before diving into advanced protocols, your body needs the right foundations in place.
This bundle is a practitioner-informed starting point designed to support methylation, manage start-up side effects, and keep your methylation running smoothly.†
$92
$92 - $92
$92
$73.60
$73.60 - $73.60
$73.60

See what's included?

Methyl B12 with L-Methylfolate
901 Reviews

Methyl B12 with L-Methylfolate
Optimal Electrolyte Strawberry Watermelon Container | Strawberry Watermelon / 1 Pack, Strawberry Watermelon / 3 Pack, Strawberry Watermelon / 6 Pack
1702 Reviews

Optimal Electrolyte
Riboflavin Supplement Bottle
126 Reviews

Riboflavin
Third Party Tested Third Party Tested
High End Ingredients High End Ingredients
60-day Return Policy 60-day Return Policy
Free Shipping Free Shipping

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Methyl B12 with L-Methylfolate
4.9
Rated 4.9 out of 5 stars
901 Reviews
| Review Summary

Methyl B12 with L-Methylfolate

The foundation of your MTHFR bundle — combines active B12 and methylfolate in one
$27 Best Seller

What it does for MTHFR:

MTHFR variants reduce your ability to convert folic acid and B12 into their active forms. Methyl B12 and L-methylfolate bypass that broken step, feeding directly into the methylation cycle to support neurotransmitter production, detox, and homocysteine regulation.†

When To Take:

First thing in the morning on an empty stomach or between meals. This is considered the foundational supplement in your bundle — many practitioners recommend starting it 1–2 weeks before adding the others.

How To Take:

Let it dissolve fully for best absorption then swallow. Start low and increase gradually over days or weeks.

Signs you may be taking too little:

Persistent fatigue, brain fog, or low mood. You may not feel any noticeable difference from baseline.

Signs you may be taking too much (overmethylation):

Restlessness, poor sleep, or feeling “wired.” Some people may experience headaches. Scale back the dose if these appear — finding your individual sweet spot matters.
Riboflavin
4.9
Rated 4.9 out of 5 stars
126 Reviews
| Review Summary

Riboflavin

Keeps the MTHFR enzyme itself running smoothly — the often-overlooked essential
$25

What it does for MTHFR:

Riboflavin is the cofactor that the MTHFR enzyme itself needs to function. Think of it as the oil that keeps the engine running. This is especially important for the A1298C variant but benefits C677T as well. Often overlooked but arguably foundational.†

When To Take:

With a meal (it absorbs better with food). Morning or midday is fine. Take it alongside the other supplements in your bundle.

How To Take:

Swallow with food. Don’t be alarmed — your urine will turn bright fluorescent yellow. This is completely normal and harmless; it’s just excess riboflavin being excreted.

Signs you may be taking too little:

The other supplements in your bundle don’t seem to be working as well as expected, fatigue, or you have the A1298C variant and aren’t seeing any benefits.

Signs you may be taking too much:

B2 is water-soluble and very well tolerated, so toxicity is rare. Occasional digestive upset or diarrhea at very high doses. If urine is constantly neon, you may be taking more than your body can use — you could try reducing to 50 mg.
Optimal Electrolyte
4.6
Rated 4.6 out of 5 stars
1,702 Reviews
| Review Summary

Optimal Electrolyte

Prepares your body to handle methylation support smoothly
$40 Best Seller

What it does for MTHFR:

When you start methylation support, you're giving your body tools for healthy detoxification. Electrolytes help your kidneys and cells handle that increased detox load and support a healthy response to “start-up” side effects like headaches, fatigue, and irritability.†

When To Take:

First thing in the morning or between meals. Many practitioners recommend starting this before the other supplements in your bundle — ideally 1–2 weeks ahead — to prepare your system.

How To Take:

Mix into water as directed on the label. Sip throughout the day rather than drinking it all at once.

Signs you may be taking too little:

You feel headachy, crampy, or fatigued when you start the methylfolate/B12, or you get “detox” symptoms like brain fog and irritability.

Signs you may be taking too much

Loose stools or digestive upset, feeling overly flushed, or any nausea. Magnesium-containing electrolytes in particular will cause loose stool at excess doses.

What This BundleHelps Address

  • Methyl B12 with L-Methylfolate — The foundation of your MTHFR bundle — combines active B12 and methylfolate in one
  • Optimal Electrolyte — Prepares your body to handle methylation support smoothly
  • Riboflavin (B2) — Keeps the MTHFR enzyme itself running smoothly — the often-overlooked essential

It’s about giving your methylation cycle what it actually needs — so you can stop guessing and start feeling the difference.†

What Our Customers Say

Sydney F.
First time taking Riboflavin
I have mildly elevated blood pressure (Dr. keeping an eye on) which I think could possibly be due to MTHFR gene mutation. I am hoping by taking Riboflavin my blood pressure will go down over time. There are many other benefits to taking Riboflavin so it's still a win no matter what.
ziyad
Optimal Electrolyte
The new flavor is great, and the minerals keep me feeling good hydrated after sauna !
Deneige
Great electrolytes
I feel good about the ingredients and enjoy the flavor. I drink these every morning to stay hydrated while navigating chronic illnesses. I recommend this product.
Stacy S.
B12 clean ingredients and 3rd party tested
I’m happy with my purchase . I needed B12 and I’m really trying to only purchase clean ingredients and 3rd tested products . This fit that requirement. I’m very happy with my purchase

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When the foundation is supported
everything works better
Start with daily, genetics-informed nutrients.

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